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Target
Bone morphogenetic protein receptor type-1A
Ligand
BDBM148371
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
370±n/a nM
Citation
 Alimardanov, A; Cuny, GD; Grewal, GS; Lee, A; McKew, JC; Mohedas, AH; Shen, M; Xu, X; Yu, PB BMP inhibitors and methods of use thereof US Patent  US10017516 Publication Date 7/10/2018 
Target
Name:
Bone morphogenetic protein receptor type-1A
Synonyms:
BMR1A_HUMAN | BMPR1A | ACVRLK3 | ALK3 | Activin receptor-like kinase 3 (ALK-3)
Type:
Enzyme
Mol. Mass.:
60204.46
Organism:
Human
Description:
P36894
Residue:
532
Sequence:
MPQLYIYIRLLGAYLFIISRVQGQNLDSMLHGTGMKSDSDQKKSENGVTLAPEDTLPFLKCYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQCKDSPKAQLRRTIECCRTNLCNQYLQPTLPPVVIGPFFDGSIRWLVLLISMAVCIIAMIIFSSCFCYKHYCKSISSRRRYNRDLEQDEAFIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQGKPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPEVLDESLNKNHFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYEDMREVVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTLAKMVESQDVKI
  
Inhibitor
Name:
BDBM148371
Synonyms:
US9682983, 32 | US10017516, Compound 32
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
CC(C)(CN1CCCCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1cccc2ncccc12
Structure:
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