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Target
Activin receptor type-1
Ligand
BDBM148387
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
46.0±n/a nM
Citation
 Alimardanov, A; Cuny, GD; Grewal, GS; Lee, A; McKew, JC; Mohedas, AH; Shen, M; Xu, X; Yu, PB BMP inhibitors and methods of use thereof US Patent  US10017516 Publication Date 7/10/2018 
Target
Name:
Activin receptor type-1
Synonyms:
ACVR1 | Activin receptor type I | Activin receptor-like kinase 2 | Serine/threonine-protein kinase receptor R1 | TGF-B superfamily receptor type I | TSR-I | Q04771 | 2.7.11.30 | Activin receptor-like kinase 2 (ALK2/ACVR1) | Activin receptor-like kinase 2 (ALK-2) | SKR1 | ALK-2 | ACVR1_HUMAN | ACVRLK2 | ALK2/ACVR1 | ACTR-I
Type:
n/a
Mol. Mass.:
57158.32
Organism:
Human
Description:
n/a
Residue:
509
Sequence:
MVDGVMILPVLIMIALPSPSMEDEKPKVNPKLYMCVCEGLSCGNEDHCEGQQCFSSLSINDGFHVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQLPTKGKSFPGTQNFHLEVGLIILSVVFAVCLLACLLGVALRKFKRRNQERLNPRDVEYGTIEGLITTNVGDSTLADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDNSLDKLKTDC
  
Inhibitor
Name:
BDBM148387
Synonyms:
US9682983, 36 | US10017516, Compound 36
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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