Reaction Details Report a problem with these data
Target
Sodium-dependent serotonin transporter
Ligand
BDBM22417
Substrate
n/a
Ki
158±n/a nM
Comments
PDSP_1329
Citation
 Davids, E; Zhang, K; Kula, NS; Tarazi, FI; Baldessarini, RJ Effects of norepinephrine and serotonin transporter inhibitors on hyperactivity induced by neonatal 6-hydroxydopamine lesioning in rats. J Pharmacol Exp Ther 301:1097-102 (2002) [PubMed]  Article 
Target
Name:
Sodium-dependent serotonin transporter
Synonyms:
5-HT Transporter | 5-HTT | 5HT transporter | 5HTT | Anandamid membrane transporter, AMT | Anandamide membrane transporter, AMT | Sodium-dependent serotonin transporter (SERT) | imipramine receptor | SC6A4_RAT | Slc6a4 | Sodium-dependent serotonin transporter | Monoamine transporters; Norepinephrine & serotonin
Type:
Multi-pass membrane protein
Mol. Mass.:
70168.43
Organism:
Rat
Description:
P31652
Residue:
630
Sequence:
METTPLNSQKVLSECKDREDCQENGVLQKGVPTTADRAEPSQISNGYSAVPSTSAGDEASHSIPAATTTLVAEIRQGERETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIIAWALYYLISSLTDRLPWTSCTNSWNTGNCTNYFAQDNITWTLHSTSPAEEFYLRHVLQIHQSKGLQDLGTISWQLTLCIVLIFTVIYFSIWKGVKTSGKVVWVTATFPYIVLSVLLVRGATLPGAWRGVVFYLKPNWQKLLETGVWVDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWAKRREWFVLIVVITCVLGSLLTLTSGGAYVVTLLEEYATGPAVLTVALIEAVAVSWFYGITQFCSDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPHWSIVLGYCIGMSSVICIPTYIIYRLISTPGTLKERIIKSITPETPTEIPCGDIRMNAV
  
Inhibitor
Name:
BDBM22417
Synonyms:
LY 94939 | Nisoxetine Inhibitor | Nisoxetine | LY139602 | 3-(2-methoxyphenoxy)-N-methyl-3-phenylpropan-1-amine | LY 135252 | CHEMBL295467 | LY135252 | [3-(2-methoxyphenoxy)-3-phenylpropyl](methyl)amine | [3H]Nisoxetine | US9944618, Compound ID No. 177
Type:
radiolabeled ligand
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: