Reaction Details
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Serine/threonine-protein kinase Chk1
Ligand
BDBM91953
Substrate
n/a
Meas. Tech.
Abbott Kinase Enzymatics_CHK1/289 CDC25c
IC50
11±n/a nM
Citation
CSARdock, CD CHK1 in CSAR_FULL_RELEASE_3JULY2012 CSAR 1:0 (2012) More Info.:
Target
Name:
Serine/threonine-protein kinase Chk1
Synonyms:
CHK1 checkpoint homolog | Checkpoint kinase-1 (CHK1)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
54443.02
Organism:
Homo sapiens (Human)
Description:
gi_166295192
Residue:
476
Sequence:
MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDFSPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLLGTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRRNNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
Inhibitor
Name:
BDBM91953
Synonyms:
Chk1_85
Type:
n/a
Emp. Form.:
C18H18ClN5O4
Mol. Mass.:
403.82
SMILES:
OC1CCCC(Oc2ccc(Cl)cc2NC(=O)Nc2cnc(cn2)C#N)C1O
Structure:
