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Target
Phosphoethanolamine N-methyltransferase 1
Ligand
BDBM50034220
Substrate
n/a
Meas. Tech.
Radiochemical Assay
pH
8.0000±0.0000
Temperature
298.1500±0.0000 K
IC50
1.252e+5± 8.8e+3 nM
Citation
 Lee, SG; Haakenson, W; McCarter, JP; Williams, DJ; Hresko, MC; Jez, JM Thermodynamic evaluation of ligand binding in the plant-like phosphoethanolamine methyltransferases of the parasitic nematode Haemonchus contortus. J Biol Chem 286:38060-8 (2011) [PubMed]  Article 
Target
Name:
Phosphoethanolamine N-methyltransferase 1
Synonyms:
Phosphoehtnaolamine Methyltransferases 1 (PMT1)
Type:
Enzyme
Mol. Mass.:
53531.36
Organism:
Caenorhabditis elegans
Description:
Q86NB3
Residue:
475
Sequence:
MSTDQQSSVEDQTVAMVNVRRANFKSFWDKYSDKPDTNSMMLNHSAEELESSDRADILASLPLLHNKDVVDIGAGIGRFTTVLAETARWVLSTDFIDSFIKKNQERNAHLGNINYQVGDAVGLKMESNSVDLVFTNWLMMYLSDEETVEFIFNCMRWLRSHGIVHLRESCSEPSTGRSKAKSMHDTANANPTHYRFSSLYINLLRAIRYRDVDNKLWRFNVQWSCSVPTYIKRSNNWRQVHWLAEKVPAEDGAKGTSFNELVELIKNTWQNEQEAWDAKLDDEKYVWTDKVFSSALTSLPSNSTFFLYTPRTVSPYCHINAHTLAETFNANVWNTEIIPEYYRTSLTKSNNLKDQRVRFGWNQSLTDSVTYWQQKDALFDVFVATEFLSTVDDETIRQLPNVMSDGAKFITLEPVDEVNEAEMKQRIQELGYTLKSFTDVTDQCIEAQEQYFKDHEQLRDEKVIRKNWVLLELTH
  
Inhibitor
Name:
BDBM50034220
Synonyms:
n-hexadecylphosphocholine | CHEMBL125 | hexadecyl 2-(trimethylammonio)ethyl phosphate | hexadecyl 2-(trimethyl-lambda~5~-azanyl)ethyl hydrogen phosphate | [2-(Hexadecyloxy-hydroxy-phosphoryloxy)-ethyl]-trimethyl-ammonium | hexadecyloxy-2-trimethylammonioethylphosphorate | 2-(((Hexadecyloxy)hydroxyphosphinyl)oxy)-N,N,N-trimethylethanaminium hydroxide | hexadecylphosphocholine, miltefosine | hexadecylphosphocholine | MILTEFOSINE
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: