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Target
Cyclin-dependent kinase 2
Ligand
BDBM92564
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
5.3e+4± 5.7e+3 nM
Citation
 Martin, MP; Alam, R; Betzi, S; Ingles, DJ; Zhu, JY; Schönbrunn, E A Novel Approach to the Discovery of Small-Molecule Ligands of CDK2. Chembiochem 13:2128-36 (2012) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 2
Synonyms:
Cyclin-dependent kinase 2 (CDK2) | p33 protein kinase | CDK2-Kinase | Cell division protein kinase 2 | Protein cereblon/Cyclin-dependent kinase 2 | CDK2_HUMAN | CDK2 | CDKN2
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Human
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Inhibitor
Name:
BDBM92564
Synonyms:
Hit compound, 5
Type:
Small molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
COCc1cc(\N=N\c2cccc(c2)S(N)(=O)=O)c2ccccc2c1N
Structure:
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