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Target
Cyclin-dependent kinase 2
Ligand
BDBM67612
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
4.6e+4± 1.0e+4 nM
Citation
 Martin, MP; Alam, R; Betzi, S; Ingles, DJ; Zhu, JY; Schönbrunn, E A Novel Approach to the Discovery of Small-Molecule Ligands of CDK2. Chembiochem 13:2128-36 (2012) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 2
Synonyms:
Cyclin-dependent kinase 2 (CDK2) | p33 protein kinase | CDK2-Kinase | Cell division protein kinase 2 | Protein cereblon/Cyclin-dependent kinase 2 | CDK2_HUMAN | CDK2 | CDKN2
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Human
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Inhibitor
Name:
BDBM67612
Synonyms:
cid_238065 | SMR000304390 | 2-pyridin-2-ylindene-1,3-dione | MLS000719861 | 2-(2-pyridyl)indane-1,3-dione | 2-(2-pyridinyl)indene-1,3-dione | 2-(2-pyridyl)indane-1,3-quinone
Type:
Small organic molecule
Emp. Form.:
C14H9NO2
Mol. Mass.:
223.06
SMILES:
O=C1C(C(=O)c2ccccc12)c1ccccn1
Structure:
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