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Target
Cyclin-dependent kinase 2
Ligand
BDBM16673
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
>1.50e+5±n/a nM
Citation
 Martin, MP; Alam, R; Betzi, S; Ingles, DJ; Zhu, JY; Schönbrunn, E A Novel Approach to the Discovery of Small-Molecule Ligands of CDK2. Chembiochem 13:2128-36 (2012) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 2
Synonyms:
Cyclin-dependent kinase 2 (CDK2) | p33 protein kinase | CDK2-Kinase | Cell division protein kinase 2 | Protein cereblon/Cyclin-dependent kinase 2 | CDK2_HUMAN | CDK2 | CDKN2
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Human
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Inhibitor
Name:
BDBM16673
Synonyms:
BAY439006 | CHEMBL1336 | BAY 43-9006 | 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide | 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-picolinamide;tosylic acid | Sorafenib, 4 | Hit compound, 8 | Sorafenib | Nexavar | cid_216239 | BAY 439006 | US9029401, Sorafenib | US9469639, Sorafenib | US10183928, Sorafenib | US10202365, Compound Sorafenib | US10227329, Compound Sorafenib | US9902709, Comparative example 1 | US10584114, Compound Sorafenib | US10774070, Compound Sorafenib | US10980809, Example Sorafenib | US11505527, Compound Sorafenib | US11279688, Compound Sorafenib | US11912663, Compound Sorafenib | US20250129067, Compound Sorafenib
Type:
Small organic molecule
Emp. Form.:
C21H16ClF3N4O3
Mol. Mass.:
464.09
SMILES:
CNC(=O)c1cc(ccn1)Oc2ccc(cc2)NC(=O)Nc3ccc(c(c3)C(F)(F)F)Cl
Structure:
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