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Target
Cyclin-dependent kinase 2
Ligand
BDBM52831
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
>1.50e+5±n/a nM
Citation
 Martin, MP; Alam, R; Betzi, S; Ingles, DJ; Zhu, JY; Schönbrunn, E A Novel Approach to the Discovery of Small-Molecule Ligands of CDK2. Chembiochem 13:2128-36 (2012) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 2
Synonyms:
Cyclin-dependent kinase 2 (CDK2) | p33 protein kinase | CDK2-Kinase | Cell division protein kinase 2 | Protein cereblon/Cyclin-dependent kinase 2 | CDK2_HUMAN | CDK2 | CDKN2
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Human
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Inhibitor
Name:
BDBM52831
Synonyms:
cid_5385177 | MLS000757168 | SMR000529027 | Hit compound, 9 | 4-[2-(4-methylphenyl)hydrazinyl]benzotriazol-5-one | 4-[(4-methylphenyl)hydrazo]-5-benzotriazolone | 4-[N'-(p-tolyl)hydrazino]benzotriazol-5-one
Type:
Small organic molecule
Emp. Form.:
C13H11N5O
Mol. Mass.:
253.10
SMILES:
Cc1ccc(cc1)N=Nc1c(O)ccc2nn[nH]c12 |w:8.9|
Structure:
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