Reaction Details Report a problem with these data
Target
Cyclin-dependent kinase 2
Ligand
BDBM50651
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
>1.50e+5±n/a nM
Citation
 Martin, MP; Alam, R; Betzi, S; Ingles, DJ; Zhu, JY; Schönbrunn, E A Novel Approach to the Discovery of Small-Molecule Ligands of CDK2. Chembiochem 13:2128-36 (2012) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 2
Synonyms:
Cyclin-dependent kinase 2 (CDK2) | p33 protein kinase | CDK2-Kinase | Cell division protein kinase 2 | Protein cereblon/Cyclin-dependent kinase 2 | CDK2_HUMAN | CDK2 | CDKN2
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Human
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Inhibitor
Name:
BDBM50651
Synonyms:
cid_246666 | 2,6-bis(azanyl)-1,5-bis(chloranyl)anthracene-9,10-dione | SMR000528277 | MLS000737360 | 2,6-diamino-1,5-dichloroanthracene-9,10-dione | 9, 10-Anthracenedione, 2,6-diamino-1,5-dichloro- | Hit compound, 11 | 2,6-diamino-1,5-dichloro-9,10-anthraquinone
Type:
Small organic molecule
Emp. Form.:
C14H8Cl2N2O2
Mol. Mass.:
306.00
SMILES:
Nc1ccc2C(=O)c3c(Cl)c(N)ccc3C(=O)c2c1Cl
Structure:
Search PDB for entries with ligand similarity: