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Target
Tyrosine-protein kinase SYK
Ligand
BDBM92626
Substrate
n/a
Meas. Tech.
Syk Enzyme Assay
pH
7.4000±0.0000
Temperature
298.1500±0.0000 K
IC50
2.1±0.0 nM
Citation
 Lovering, F; McDonald, J; Whitlock, GA; Glossop, PA; Phillips, C; Bent, A; Sabnis, Y; Ryan, M; Fitz, L; Lee, J; Chang, JS; Han, S; Kurumbail, R; Thorarensen, A Identification of Type-II Inhibitors Using Kinase Structures. Chem Biol Drug Des 80:657-64 (2012) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase SYK
Synonyms:
Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk) | KSYK_HUMAN | SYK
Type:
Enzyme
Mol. Mass.:
72079.99
Organism:
Human
Description:
P43405
Residue:
635
Sequence:
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
  
Inhibitor
Name:
BDBM92626
Synonyms:
Pyrido analog, 3
Type:
Organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
Cc1ccc(cc1C2=Cc3cnc(nc3N(C2=O)C)Nc4ccccc4)NC(=O)c5cccc(c5)C(F)(F)F
Structure:
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