Reaction Details
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Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
Ligand
BDBM88865
Substrate
n/a
IC50
21304±n/a nM
Citation
PubChem, PC Fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 (ASAP1) PubChem Bioassay (2012)[AID] More Info.:
Target
Name:
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
Synonyms:
ASAP1_HUMAN | ASAP1 | DDEF1 | KIAA1249 | PAG2 | arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform 2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
125507.11
Organism:
Human
Description:
Q9ULH1
Residue:
1129
Sequence:
MRSSASRLSSFSSRDSLWNRMPDQISVSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLLEEALDQDRTALQKVKKSVKAIYNSGQDHVQNEENYAQVLDKFGSNFLSRDNPDLGTAFVKFSTLTKELSTLLKNLLQGLSHNVIFTLDSLLKGDLKGVKGDLKKPFDKAWKDYETKFTKIEKEKREHAKQHGMIRTEITGAEIAEEMEKERRLFQLQMCEYLIKVNEIKTKKGVDLLQNLIKYYHAQCNFFQDGLKTADKLKQYIEKLAADLYNIKQTQDEEKKQLTALRDLIKSSLQLDQKEDSQSRQGGYSMHQLQGNKEYGSEKKGYLLKKSDGIRKVWQRRKCSVKNGILTISHATSNRQPAKLNLLTCQVKPNAEDKKSFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEEALTMAFRGEQSAGENSLEDLTKAIIEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRKEYITAKYVDHRFSRKTCSTSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEPGQELGETALHLAVRTADQTSLHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLLRSKPTVDIVNQAGETALDIAKRLKATQCEDLLSQAKSGKFNPHVHVEYEWNLRQEEIDESDDDLDDKPSPIKKERSPRPQSFCHSSSISPQDKLALPGFSTPRDKQRLSYGAFTNQIFVSTSTDSPTSPTTEAPPLPPRNAGKGPTGPPSTLPLSTQTSSGSSTLSKKRPPPPPPGHKRTLSDPPSPLPHGPPNKGAVPWGNDGGPSSSSKTTNKFEGLSQQSSTSSAKTALGPRVLPKLPQKVALRKTDHLSLDKATIPPEIFQKSSQLAELPQKPPPGDLPPKPTELAPKPQIGDLPPKPGELPPKPQLGDLPPKPQLSDLPPKPQMKDLPPKPQLGDLLAKSQTGDVSPKAQQPSEVTLKSHPLDLSPNVQSRDAIQKQASEDSNDLTPTLPETPVPLPRKINTGKNKVRRVKTIYDCQADNDDELTFIEGEVIIVTGEEDQEWWIGHIEGQPERKGVFPVSFVHILSD
Inhibitor
Name:
BDBM88865
Synonyms:
SMR000185905 | 4-bromo-N'-[(E)-(3-chloro-6-oxo-1-cyclohexa-2,4-dienylidene)methyl]benzohydrazide | MLS000576521 | 4-bromanyl-N'-[(E)-(3-chloranyl-6-oxidanylidene-cyclohexa-2,4-dien-1-ylidene)methyl]benzohydrazide | 4-bromo-N'-(5-chloro-2-hydroxybenzylidene)benzohydrazide | 4-bromo-N'-[(E)-(3-chloro-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]benzohydrazide | cid_5333681 | 4-bromo-N'-[(E)-(3-chloro-6-keto-cyclohexa-2,4-dien-1-ylidene)methyl]benzohydrazide
Type:
Small organic molecule
Emp. Form.:
C14H10BrClN2O2
Mol. Mass.:
351.96
SMILES:
Oc1ccc(Cl)cc1C=NNC(=O)c1ccc(Br)cc1 |w:9.10|
Structure:
