Reaction Details Report a problem with these data
Target
3-phosphoinositide-dependent protein kinase 1 [51-359]
Ligand
BDBM281816
Substrate
n/a
Meas. Tech.
PDK1 kinase assay
IC50
<100±n/a nM
Citation
 Arndt, J; Chan, T; Guckian, K; Kumaravel, G; Lee, W; Lin, EY; Scott, D; Sun, L; Thomas, J; van Vloten, K; Wang, D; Zhang, L; Erlanson, D Heterocyclic compounds useful as PDK1 inhibitors US Patent  US10030016 Publication Date 7/24/2018 
Target
Name:
3-phosphoinositide-dependent protein kinase 1 [51-359]
Synonyms:
3-phosphoinositide-dependent protein kinase 1 (aa 51-359) | 3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) | 3-phosphoinositide-dependent protein kinase 1 | PDK1 (aa 51-359) | hPDK1 | PDPK1_HUMAN | PDPK1 | PDK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
35302.26
Organism:
Human
Description:
O15530[51-359]
Residue:
309
Sequence:
MDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPKLT
  
Inhibitor
Name:
BDBM281816
Synonyms:
2-[4-(4-Amino-7-methyl-7H- pyrrolo[2,3-d]pyrimidin-5-yl)- benzylamino]-N-[(S)-1-(3,4- difluoro-phenyl)-ethyl]- nicotinamide | US10030016, Example 2.38
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
C[C@H](NC(=O)c1cccnc1NCc1ccc(cc1)-c1cn(C)c2ncnc(N)c12)c1ccc(F)c(F)c1 |r|
Structure:
Search PDB for entries with ligand similarity: