Reaction Details Report a problem with these data
Target
Cathepsin B
Ligand
BDBM122503
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
pH
6.5000±n/a
IC50
77±n/a nM
Citation
 Banner, D; Haap, W; Kuhn, B; Luebbers, T; Peters, J; Schulz-Gasch, T Pyrrolidine derivatives US Patent  US8729061 Publication Date 5/20/2014 
Target
Name:
Cathepsin B
Synonyms:
APP secretase | APPS | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1 | CATB_HUMAN | CTSB | CPSB
Type:
Enzyme
Mol. Mass.:
37819.69
Organism:
Human
Description:
gi_63102437
Residue:
339
Sequence:
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
  
Inhibitor
Name:
BDBM122503
Synonyms:
US8729061, 33
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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