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Target
Lysine-specific demethylase 5A
Ligand
BDBM124969
Substrate
n/a
Meas. Tech.
Biological Assay
pH
7.5±n/a
Ki
12000±n/a nM
Comments
extracted
Citation
 Minucci, S; Mai, A; Mattevi, A Tranylcypromine derivatives as inhibitors of histone demethylases LSD1 and/or LSD2 US Patent  US8765820 Publication Date 7/1/2014 
Target
Name:
Lysine-specific demethylase 5A
Synonyms:
Jarid1a | KDM5A_MOUSE | Kdm5a | Lysine-specific histone demethylase 2 (LSD2) | Rbp2
Type:
Protein
Mol. Mass.:
192210.15
Organism:
Mus musculus (Mouse)
Description:
Q3UXZ9
Residue:
1690
Sequence:
MASVGPGGYAAEFVPPPECPVFEPSWEEFTDPLSFIGRIRPFAEKTGICKIRPPKDWQPPFACEVKTFRFTPRVQRLNELEAMTRVRLDFLDQLAKFWELQGSTLKIPVVERKILDLYALSKIVASKGGFEIVTKEKKWSKVGSRLGYLPGKGTGSLLKSHYERILYPYELFQSGVSLMGVQMPDLDLKEKVEAEVLSTDIQPSPERGTRMNIPPKRTRRVKSQSDSGEVNRNTELKKLQIFGAGPKVVGLAVGAKDKEDEVTRRRKVTNRSDAFNMQMRQRKGTLSVNFVDLYVCMFCGRGNNEDKLLLCDGCDDSYHTFCLLPPLPDVPKGDWRCPKCVAEECNKPREAFGFEQAVREYTLQSFGEMADNFKSDYFNMPVHMVPTELVEKEFWRLVSSIEEDVIVEYGADISSKDFGSGFPKKDGQRKMLPEEEEYALSGWNLNNMPVLEQSVLAHINVDISGMKVPWLYVGMCFSSFCWHIEDHWSYSINYLHWGEPKTWYGVPSHAAEQLEEVMRELAPELFESQPDLLHQLVTIMNPNVLMEHGVPVYRTNQCAGEFVVTFPRAYHSGFNQGYNFAEAVNFCTADWLPIGRQCVNHYRRLRRHCVFSHEELIFKMAADPECLDVGLAAMVCKELTLMTEEETRLRESVVQMGVVMSEEEVFELVPDDERQCSACRTTCFLSALTCSCNPERLVCLYHPTDLCSCPMQNKCLRYRYPLEDLPSLLYGVKVRAQSYDTWVNRVTEALSASFNHKKDLIELRVMLEDAEDRKYPENDLFRKLRDAVKEAETCGSVAQLLLSKKQKHRQSSDSGKTRTKLTVEELKAFVQQLVSLPCVISQTRQVKNLLDDVEEFHERAQEAMMDETPDSSKLQMLIDMGSSLYVELPELPRLKQELQQARWLDEVRLTLSDPQQVTLDVMKKLIDSGVGLAPHHAVEKAMAELQELLTVSERWEEKAKVCLQARPRHSMANLENIVNEAKNIPAFLPNVLSLKEALQKAREWTAKVEAIQSGNNYAYLEQLESLSAKGRPIPVRLDALPQVESQVAAARAWRERTGRTFLKKNSSHTLLQVLSPRTDIGVYGSGKNRRKKVKEIIEKEKEKDLDLEPLSDLEEGLEESRDTAMVVAVFKEREQKEIEAMHSLRAANLAKMTIVERIEEVKFCICRKTASGFMLQCELCKDWFHNSCVPLPKSSSQKKGSSWQAKDVKFLCPLCMRSRRPRLETILSLLVSLQKLPVRLPEGEALQCLTERAMSWQDKARQALATDELSSALAKLSVLSQRMVEQAAREKTEKIISAELQKAAANPDLQGHLPSFQQSAFNRVVSSVSSSPHQTMDYDDEETDSDEDIRETYGYDMKDTASVKSSSSLEPNLFCDEEIPIKSEEVVTHMWTAPSFCAEHAYSSASKSCSQGSSTPRKQPRKSPLVPRSLEPPVLELSPGAKAQLEELMMVGDLLEVSLDETQHIWRILQATHPPSEDRFLHIMEDDSIEEKPLKMKGKDSSEKKRKRKLEKVEQLFGEGKQKTKELKKIDKPKKKKLKLNVDKSKELNKLAKKLAKEEERKKKKEKAAAAKVELVKESTEKKRERKVLDIPSKYDWSGAEESDDENAVCAAQNCQRPCKDKVDWVQCDGGCDEWFHQVCVGVSAEMAENEDYICINCAKKQGPDSPGQAPPPPFLMSYKLPMEDLKETS
  
Inhibitor
Name:
BDBM124969
Synonyms:
US8765820, 6l
Type:
Small organic molecule
Emp. Form.:
C28H28N4O3
Mol. Mass.:
468.5469
SMILES:
NC1CC1c1ccc(NC(=O)C(Cc2c[nH]c3ccccc23)NC(=O)COc2ccccc2)cc1
Structure:
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