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Target
E3 ubiquitin-protein ligase XIAP
Ligand
BDBM139062
Substrate
n/a
Meas. Tech.
Fluorescence Polarization (FP) Based Competitive Assay
pH
7.5000±n/a
IC50
<10±n/a nM
Comments
extracted
Citation
 Wang, S; Sheng, R; Sun, H; Liu, L; Lu, J; McEachern, D Bivalent inhibitors of IAP proteins and therapeutic methods using the same US Patent  US8883771 Publication Date 11/11/2014 
Target
Name:
E3 ubiquitin-protein ligase XIAP
Synonyms:
Inhibitor of apoptosis protein 3 | Inhibitor of apoptosis protein 3 (XIAP) | E3 ubiquitin-protein ligase XIAP | X-linked inhibitor of apoptosis | XIAP_HUMAN | XIAP | API3 | BIRC4 | IAP3 | X-linked inhibitor of apoptosis protein (XIAP)
Type:
Protein
Mol. Mass.:
56685.27
Organism:
Human
Description:
P98170
Residue:
497
Sequence:
MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS
  
Inhibitor
Name:
BDBM139062
Synonyms:
US8883771, 8
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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