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Target
Baculoviral IAP repeat-containing protein 3
Ligand
BDBM139058
Substrate
n/a
Meas. Tech.
Fluorescence Polarization (FP) Based Competitive Assay
pH
7.5000±n/a
IC50
<100±n/a nM
Comments
extracted
Citation
 Wang, S; Sheng, R; Sun, H; Liu, L; Lu, J; McEachern, D Bivalent inhibitors of IAP proteins and therapeutic methods using the same US Patent  US8883771 Publication Date 11/11/2014 
Target
Name:
Baculoviral IAP repeat-containing protein 3
Synonyms:
Baculoviral IAP repeat-containing protein 3 | Inhibitor of apoptosis protein 3 (cIAP2) | cIAP1/cIAP2 | BIRC3_HUMAN | BIRC3 | API2 | MIHC | RNF49 | Baculoviral IAP repeat-containing protein 3 (IAP1 BIR3) | XIAP-BIR3
Type:
Protein
Mol. Mass.:
68365.75
Organism:
Human
Description:
Q13489
Residue:
604
Sequence:
MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS
  
Inhibitor
Name:
BDBM139058
Synonyms:
US8883771, 4
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
CN[C@@H](C)C(=O)N[C@H]1CN(CC[C@H]2CCC(N2C1=O)C(=O)N[C@@H]1CCCc2ccccc12)C(=O)NCCCCCCCCNC(=O)N1CC[C@H]2CC[C@H](N2C(=O)[C@H](C1)NC(=O)[C@H](C)NC)C(=O)N[C@@H]1CCCc2ccccc12 |r|
Structure:
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