Reaction Details Report a problem with these data
Target
Dihydroorotase
Ligand
BDBM154573
Substrate
n/a
Meas. Tech.
Inhibitor Selectivity Assay
pH
7.5000±n/a
IC50
>1.00e+5±n/a nM
Comments
extracted
Citation
 Lee, H; Lei, H; Santarsiero, BD; Gatuz, JL; Cao, S; Rice, AJ; Patel, K; Szypulinski, MZ; Ojeda, I; Ghosh, AK; Johnson, ME Inhibitor recognition specificity of MERS-CoV papain-like protease may differ from that of SARS-CoV. ACS Chem Biol 10:1456-65 (2015) [PubMed]  Article 
Target
Name:
Dihydroorotase
Synonyms:
PYRC_BACAN | pyrC | Dihydroorotase (PyrC)
Type:
Protein
Mol. Mass.:
46646.28
Organism:
Bacillus anthracis
Description:
n/a
Residue:
428
Sequence:
MNYLFKNGRYMNEEGKIVATDLLVQDGKIAKVAENITADNAEVIDVNGKLIAPGLVDVHVHLREPGGEHKETIETGTLAAAKGGFTTICAMPNTRPVPDCREHMEDLQNRIKEKAHVNVLPYGAITVRQAGSEMTDFETLKELGAFAFTDDGVGVQDASMMLAAMKRAAKLNMAVVAHCEENTLINKGCVHEGKFSEKHGLNGIPSVCESVHIARDILLAEAADCHYHVCHVSTKGSVRVIRDAKRAGIKVTAEVTPHHLVLCEDDIPSADPNFKMNPPLRGKEDHEALIEGLLDGTIDMIATDHAPHTAEEKAQGIERAPFGITGFETAFPLLYTNLVKKGIITLEQLIQFLTEKPADTFGLEAGRLKEGRTADITIIDLEQEEEIDPTTFLSKGKNTPFAGWKCQGWPVMTIVGGKIAWQKESALV
  
Inhibitor
Name:
BDBM154573
Synonyms:
8-(trifluoromethyl)-9H-purin-6-amine (4) | jm5b01461, Compound 188 | acs.jmedchem.1c00409_ST.555
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
Nc1ncnc2[nH]c(nc12)C(F)(F)F
Structure:
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