Reaction Details Report a problem with these data
Target
Cyclin-dependent kinase 2 [C118L,A144C]
Ligand
BDBM154576
Substrate
n/a
Meas. Tech.
ITC Assay
pH
7.5000±0.0000
Temperature
1107.6000±0.0000 K
Kd
9.7±0.8 nM
Citation
 Alexander, LT; Möbitz, H; Drueckes, P; Savitsky, P; Fedorov, O; Elkins, JM; Deane, CM; Cowan-Jacob, SW; Knapp, S Type II Inhibitors Targeting CDK2. ACS Chem Biol 10:2116-25 (2015) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 2 [C118L,A144C]
Synonyms:
CDK2_HUMAN | CDK2 | CDKN2 | Cyclin-dependent protein kinase 2 variant (CDK2 C118L/A144C)
Type:
Protein
Mol. Mass.:
33980.25
Organism:
Human
Description:
CDK2 mutant (C118L/A144C)
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFLHSHRVLHRDLKPQNLLINTEGAIKLCDFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Inhibitor
Name:
BDBM154576
Synonyms:
K03861 (1)
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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