Target
Cyclin-dependent kinase 2 [C118L,A144C]
Ligand
BDBM154576
Substrate
n/a
Meas. Tech.
EMSA
pH
7.5±n/a
IC50
8e+2±n/a nM
Comments
extracted
Citation
 Alexander, LTM÷bitz, HDrueckes, PSavitsky, PFedorov, OElkins, JMDeane, CMCowan-Jacob, SWKnapp, S Type II Inhibitors Targeting CDK2. ACS Chem Biol 10:2116-25 (2015) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 2 [C118L,A144C]
Synonyms:
CDK2 | CDK2_HUMAN | CDKN2 | Cyclin-dependent protein kinase 2 variant (CDK2 C118L/A144C)
Type:
Protein
Mol. Mass.:
33980.25
Organism:
Homo sapiens (Human)
Description:
CDK2 mutant (C118L/A144C)
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFLHSHRVLHRDLKPQNLLINTEGAIKLCDFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Inhibitor
Name:
BDBM154576
Synonyms:
K03861 (1)
Type:
Small organic molecule
Emp. Form.:
C24H26F3N7O2
Mol. Mass.:
501.5041
SMILES:
CN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4ccnc(N)n4)cc3)cc2C(F)(F)F)CC1
Structure:
Search PDB for entries with ligand similarity: