Reaction Details Report a problem with these data
Target
Caspase-7
Ligand
BDBM160808
Substrate
n/a
Meas. Tech.
Fluorometric Enzymatic Assay
Temperature
310.1500±n/a K
IC50
700±n/a nM
Comments
extracted
Citation
 Ahlfors, J; Mekouar, K Selective caspase inhibitors and uses thereof US Patent  US9045524 Publication Date 6/2/2015 
Target
Name:
Caspase-7
Synonyms:
Caspase | caspase 7, apoptosis-related cysteine peptidase | CMH-1 | CASP-7 | Apoptotic protease Mch-3 | CASP7_HUMAN | CASP7 | MCH3
Type:
Enzyme
Mol. Mass.:
34273.91
Organism:
Human
Description:
P55210
Residue:
303
Sequence:
MADDQGCIEEQGVEDSANEDSVDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELYFSQ
  
Inhibitor
Name:
BDBM160808
Synonyms:
US9045524, 76 | US10167313, Compound 76
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
CC(C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(O)=O)\C=C\S(C)(=O)=O |r|
Structure:
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