Reaction Details Report a problem with these data
Target
Ribonuclease pancreatic
Ligand
BDBM173613
Substrate
n/a
Meas. Tech.
Ribonuclease Activity Assay
Temperature
303.15±n/a K
Ki
1.061e+5± 6.9e+3 nM
Comments
extracted
Citation
 Chatzileontiadou, DS; Parmenopoulou, V; Manta, S; Kantsadi, AL; Kylindri, P; Griniezaki, M; Kontopoulou, F; Telopoulou, A; Prokova, H; Panagopoulos, D; Boix, E; Balatsos, NA; Komiotis, D; Leonidas, DD Triazole double-headed ribonucleosides as inhibitors of eosinophil derived neurotoxin. Bioorg Chem 63:152-65 (2015) [PubMed]  Article 
Target
Name:
Ribonuclease pancreatic
Synonyms:
CAM-RNase A | RNAS1_BOVIN | RNASE1 | RNAse A | RNS1
Type:
Enzyme
Mol. Mass.:
16468.79
Organism:
Bison bison (American bison)
Description:
carboxamidomethylated RNase A
Residue:
150
Sequence:
MALKSLVLLSLLVLVLLLVRVQPSLGKETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYVPVHFDASV
  
Inhibitor
Name:
BDBM173613
Synonyms:
9-[3'-[4-[(Uracil-1-yl)methyl]-1,2,3-triazol-1-yl]-b-D-ribofuranosyl]adenine (12a)
Type:
Small organic molecule
Emp. Form.:
C17H20N10O5
Mol. Mass.:
444.4047
SMILES:
NC1=NC=NC2C1N=CN2[C@@H]1O[C@H](CO)[C@@H](C1O)n1cc(Cn2ccc(=O)[nH]c2=O)nn1 |r,c:3,8,t:1|
Structure:
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