Reaction Details Report a problem with these data
Target
Proto-oncogene tyrosine-protein kinase Src [251-533]
Ligand
BDBM185672
Substrate
n/a
Meas. Tech.
Kinome-Wide Inhibitor Profiling
Kd
15±3 nM
Citation
 Kwarcinski, FE; Brandvold, KR; Phadke, S; Beleh, OM; Johnson, TK; Meagher, JL; Seeliger, MA; Stuckey, JA; Soellner, MB Conformation-Selective Analogues of Dasatinib Reveal Insight into Kinase Inhibitor Binding and Selectivity. ACS Chem Biol 11:1296-304 (2016) [PubMed]  Article 
Target
Name:
Proto-oncogene tyrosine-protein kinase Src [251-533]
Synonyms:
SRC_CHICK | SRC | Proto-oncogene tyrosine-protein kinase Src (c-Src) | Proto-oncogene tyrosine-protein kinase Src
Type:
Protein
Mol. Mass.:
32360.42
Organism:
Chicken
Description:
Wild-type chicken c-Src kinase domain (251-533aa)
Residue:
283
Sequence:
QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
  
Inhibitor
Name:
BDBM185672
Synonyms:
DAS-CHO-I
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
Cc1nc(cc(n1)N2CCN(CC2)CCO)Nc3ncc(s3)C(=O)Nc4ccc(cc4)Oc5ccccc5
Structure:
Search PDB for entries with ligand similarity: