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Target
Proto-oncogene tyrosine-protein kinase Src [251-533]
Ligand
BDBM185676
Substrate
n/a
Meas. Tech.
End Point Fluorescence Assay
pH
8.0000±n/a
Kd
2.8±0.0 nM
Comments
extracted
Citation
 Kwarcinski, FE; Brandvold, KR; Phadke, S; Beleh, OM; Johnson, TK; Meagher, JL; Seeliger, MA; Stuckey, JA; Soellner, MB Conformation-Selective Analogues of Dasatinib Reveal Insight into Kinase Inhibitor Binding and Selectivity. ACS Chem Biol 11:1296-304 (2016) [PubMed]  Article 
Target
Name:
Proto-oncogene tyrosine-protein kinase Src [251-533]
Synonyms:
SRC_CHICK | SRC | Proto-oncogene tyrosine-protein kinase Src (c-Src) | Proto-oncogene tyrosine-protein kinase Src
Type:
Protein
Mol. Mass.:
32360.42
Organism:
Chicken
Description:
Wild-type chicken c-Src kinase domain (251-533aa)
Residue:
283
Sequence:
QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
  
Inhibitor
Name:
BDBM185676
Synonyms:
DAS-DFGO-II-BODIPY
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
Cc1cc(C)n2c1C=C1C=CC(CCC(=O)N3CCN(CC3)c3cc(Nc4ncc(s4)C(=O)Nc4cc(NC(=O)c5cccc(c5)C(F)(F)F)ccc4C)nc(C)n3)=[N+]1[B-]2(F)F |c:10,63,t:8|
Structure:
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