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Target
Proto-oncogene tyrosine-protein kinase Src [251-533]
Ligand
BDBM50322535
Substrate
n/a
Meas. Tech.
Kinome-Wide Inhibitor Profiling for Phosphorylated c-Abl
Kd
0.7±0.1 nM
Citation
 Kwarcinski, FE; Brandvold, KR; Phadke, S; Beleh, OM; Johnson, TK; Meagher, JL; Seeliger, MA; Stuckey, JA; Soellner, MB Conformation-Selective Analogues of Dasatinib Reveal Insight into Kinase Inhibitor Binding and Selectivity. ACS Chem Biol 11:1296-304 (2016) [PubMed]  Article 
Target
Name:
Proto-oncogene tyrosine-protein kinase Src [251-533]
Synonyms:
SRC_CHICK | SRC | Proto-oncogene tyrosine-protein kinase Src (c-Src) | Proto-oncogene tyrosine-protein kinase Src
Type:
Protein
Mol. Mass.:
32360.42
Organism:
Chicken
Description:
Wild-type chicken c-Src kinase domain (251-533aa)
Residue:
283
Sequence:
QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
  
Inhibitor
Name:
BDBM50322535
Synonyms:
3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | CHEMBL1171837 | PONATINIB | US9255107, AP24534 | US10464902, Ponatinib
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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