Reaction Details Report a problem with these data
Target
Cytochrome b
Ligand
BDBM192014
Substrate
n/a
Meas. Tech.
Cytochrome b Enzyme Assay
pH
7.4000±n/a
Temperature
298.1500±n/a K
IC50
289±n/a nM
Comments
extracted
Citation
 Vincent, BM; Langlois, JB; Srinivas, R; Lancaster, AK; Scherz-Shouval, R; Whitesell, L; Tidor, B; Buchwald, SL; Lindquist, S A Fungal-Selective Cytochrome bc1 Inhibitor Impairs Virulence and Prevents the Evolution of Drug Resistance. Cell Chem Biol 23:978-991 (2016) [PubMed]  Article 
Target
Name:
Cytochrome b
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
43717.83
Organism:
Yeast
Description:
n/a
Residue:
387
Sequence:
MPTRKSNTYLSLVNSYLIDSPQPSSINYWWNLGSLLGLCLVIQIASGVFLAMHYSSNIELAFDSVEHIMRDVNAGWLIRYIHANGASFFFICMYLHIGKALYYGSYKQPRVMLWVIGVVIFILTMAIAFMGYCLVYGQMSHWGATVITNLLSAIPFIGNDIVPFIWGGFSVSNPTIQRFFALHFLLPFILAALVCMHLMALHVHGSSNPVGITGNIDRLPMHPYFIFKDLITVFVFLLIFSLFVFYSPNTLGHPDNYIPGNPMVTPPSIVPEWYLLPFYAILRSIPDKLGGVIAMFGAILILLSLPYTDRSIIRGNSFKVLSKLAFYLFVFNFILLGNLGQLHVEVPYIQLGQFATAYYFAHYIIVVPVISTLENILYYIGTQTRVK
  
Inhibitor
Name:
BDBM192014
Synonyms:
Inz-5
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
Cc1cccc2c(nn(Cc3nnn(C)n3)c12)-c1cc(ccc1F)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: