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Target
D-3-phosphoglycerate dehydrogenase
Ligand
BDBM195607
Substrate
n/a
Meas. Tech.
PHGDH Inhibition Assay
pH
8.0000±n/a
Temperature
298.1500±n/a K
IC50
>5.7e+4±n/a nM
Comments
extracted
Citation
 Pacold, ME; Brimacombe, KR; Chan, SH; Rohde, JM; Lewis, CA; Swier, LJ; Possemato, R; Chen, WW; Sullivan, LB; Fiske, BP; Cho, S; Freinkman, E; Birsoy, K; Abu-Remaileh, M; Shaul, YD; Liu, CM; Zhou, M; Koh, MJ; Chung, H; Davidson, SM; Luengo, A; Wang, AQ; Xu, X; Yasgar, A; Liu, L; Rai, G; Westover, KD; Vander Heiden, MG; Shen, M; Gray, NS; Boxer, MB; Sabatini, DM A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate. Nat Chem Biol 12:452-8 (2016) [PubMed]  Article 
Target
Name:
D-3-phosphoglycerate dehydrogenase
Synonyms:
SERA_HUMAN | PHGDH | PGDH3 | D-3-phosphoglycerate dehydrogenase | Phosphoglycerate dehydrogenase (PHGDH)
Type:
Protein
Mol. Mass.:
56650.89
Organism:
Human
Description:
n/a
Residue:
533
Sequence:
MAFANLRKVLISDSLDPCCRKILQDGGLQVVEKQNLSKEELIAELQDCEGLIVRSATKVTADVINAAEKLQVVGRAGTGVDNVDLEAATRKGILVMNTPNGNSLSAAELTCGMIMCLARQIPQATASMKDGKWERKKFMGTELNGKTLGILGLGRIGREVATRMQSFGMKTIGYDPIISPEVSASFGVQQLPLEEIWPLCDFITVHTPLLPSTTGLLNDNTFAQCKKGVRVVNCARGGIVDEGALLRALQSGQCAGAALDVFTEEPPRDRALVDHENVISCPHLGASTKEAQSRCGEEIAVQFVDMVKGKSLTGVVNAQALTSAFSPHTKPWIGLAEALGTLMRAWAGSPKGTIQVITQGTSLKNAGNCLSPAVIVGLLKEASKQADVNLVNAKLLVKEAGLNVTTSHSPAAPGEQGFGECLLAVALAGAPYQAVGLVQGTTPVLQGLNGAVFRPEVPLRRDLPLLLFRTQTSDPAMLPTMIGLLAEAGVRLLSYQTSLVSDGETWHVMGISSLLPSLEAWKQHVTEAFQFHF
  
Inhibitor
Name:
BDBM195607
Synonyms:
PHGDH-inactive | US11225469, Compound 71
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
Cc1cc(C)nc(NC(=S)N2CCN(CC2)c2ccncc2)c1
Structure:
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