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Target
Tyrosine-protein kinase JAK1 [837-1142]
Ligand
BDBM197716
Substrate
n/a
Meas. Tech.
Kinase Assay
pH
7.8±n/a
Temperature
298.15±n/a K
IC50
3.9±0 nM
Comments
extracted
Citation
 Li, Y; Rodgers, JD 3-[4-(7H-pyrrolo[2,3-D]pyrimidin-4-yl)-1H-pyrazol-1-yl]octane—or heptane-nitrile as JAK inhibitors US Patent  US9216984 Publication Date 12/22/2015 
Target
Name:
Tyrosine-protein kinase JAK1 [837-1142]
Synonyms:
JAK1 | JAK1 (aa 837-1142) | JAK1A | JAK1B | JAK1_HUMAN | Tyrosine-protein kinase JAK1 | Tyrosine-protein kinase JAK1 (837-1142) | Tyrosine-protein kinase JAK1 (aa 837-1142)
Type:
n/a
Mol. Mass.:
35230.04
Organism:
Homo sapiens (Human)
Description:
P23458[837-1142]
Residue:
306
Sequence:
FFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSF
  
Inhibitor
Name:
BDBM197716
Synonyms:
US9216984, 1
Type:
Small organic molecule
Emp. Form.:
C17H20N6
Mol. Mass.:
308.3809
SMILES:
CCCCCC(CC#N)n1cc(cn1)-c1ncnc2[nH]ccc12
Structure:
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