Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase JAK2 [828-1132]
Ligand
BDBM197717
Substrate
n/a
Meas. Tech.
Kinase Assay
pH
7.8±n/a
Temperature
298.15±n/a K
IC50
1.4±0 nM
Comments
extracted
Citation
 Li, Y; Rodgers, JD 3-[4-(7H-pyrrolo[2,3-D]pyrimidin-4-yl)-1H-pyrazol-1-yl]octane—or heptane-nitrile as JAK inhibitors US Patent  US9216984 Publication Date 12/22/2015 
Target
Name:
Tyrosine-protein kinase JAK2 [828-1132]
Synonyms:
JAK2 | JAK2 (aa 828-1132) | JAK2_HUMAN | Tyrosine-protein kinase JAK2
Type:
n/a
Mol. Mass.:
35579.28
Organism:
Homo sapiens (Human)
Description:
O60674[828-1132]
Residue:
305
Sequence:
GALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
  
Inhibitor
Name:
BDBM197717
Synonyms:
US9216984, 2
Type:
Small organic molecule
Emp. Form.:
C16H18N6
Mol. Mass.:
294.3543
SMILES:
CCCCC(CC#N)n1cc(cn1)-c1ncnc2[nH]ccc12
Structure:
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