Reaction Details Report a problem with these data
Target
Aldo-keto reductase family 1 member B10
Ligand
BDBM200220
Substrate
n/a
Meas. Tech.
IC50-Activity Assay (AKR1B10)
pH
7.0000±n/a
IC50
4.3e+2± 4e+1 nM
Comments
extracted
Citation
 Cousido-Siah, A; Ruiz, FX; Franflík, J; Giménez-Dejoz, J; Mitschler, A; Kamlar, M; Vesely´, J; Ajani, H; Parés, X; Farrés, J; Hobza, P; Podjarny, AD IDD388 Polyhalogenated Derivatives as Probes for an Improved Structure-Based Selectivity of AKR1B10 Inhibitors ACS Chem Biol 11:2693-2705 (2016) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B10
Synonyms:
Aldo-keto reductase family 1 member B10 | Small intestine reductase | ARL-1 | hARP | Aldo-keto reductase family 1 member B10 (AKR1B10) | Aldose reductase-related protein | SI reductase | Aldose reductase-like | ARP | AK1BA_HUMAN | AKR1B10 | AKR1B11 | Aldo-keto reductase family member 1B10 (AKR1B10)
Type:
Protein
Mol. Mass.:
36024.67
Organism:
Human
Description:
O60218. 1ZUA; 4JII; 4GQ0
Residue:
316
Sequence:
MATFVELSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQEKIQEKAVKREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSGDDLFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALGVSNFSHFQIEKLLNKPGLKYKPVTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEIAAKHKKTAAQVLIRFHIQRNVIVIPKSVTPARIVENIQVFDFKLSDEEMATILSFNRNWRACNVLQSSHLEDYPFNAEY
  
Inhibitor
Name:
BDBM200220
Synonyms:
2-(5-chloro-2-((2,4,6-tribromobenzyl)carbamoyl)phenoxy)acetic acid | MK184
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
c1cc(c(cc1Cl)OCC(=O)O)C(=O)NCc2c(cc(cc2Br)Br)Br
Structure:
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