Reaction Details Report a problem with these data
Target
Bcl-2-like protein 1 [1-209]
Ligand
BDBM156391
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Assay
pH
7.5000±n/a
IC50
78±n/a nM
Comments
extracted
Citation
 Diebold, RB; Gero, TW; Grover, P; Huang, S; Ioannidis, S; Ogoe, CA; Saeh, JC Chemical compounds US Patent  US9248140 Publication Date 2/2/2016 
Target
Name:
Bcl-2-like protein 1 [1-209]
Synonyms:
B2CL1_HUMAN | BCL2L1 | BCL2L | BCLX | Apoptosis regulator Bcl-XL
Type:
Protein
Mol. Mass.:
23354.38
Organism:
Human
Description:
C-terminal 6XHIS tagged Bcl-XL (aa 1-209)
Residue:
209
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQER
  
Inhibitor
Name:
BDBM156391
Synonyms:
US9018381, 14 | US9248140, 14
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
O[C@@H](C1CCN(CC1)c1ccc(cc1)C(=O)NS(=O)(=O)c1ccc(N[C@H](CCN2CCOCC2)CSc2ccccc2)c(c1)S(=O)(=O)C(F)(F)F)c1ccccc1-c1ccc(Cl)cc1 |r|
Structure:
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