Reaction Details Report a problem with these data
Target
Acyl-protein thioesterase 2 [M178L]
Ligand
BDBM207991
Substrate
n/a
Meas. Tech.
Steady-State Kinetic Assays
pH
6.5000±n/a
Ki
>10000±n/a nM
Comments
extracted
Citation
 Won, SJ; Davda, D; Labby, KJ; Hwang, SY; Pricer, R; Majmudar, JD; Armacost, KA; Rodriguez, LA; Rodriguez, CL; Chong, FS; Torossian, KA; Palakurthi, J; Hur, ES; Meagher, JL; Brooks, CL; Stuckey, JA; Martin, BR Molecular Mechanism for Isoform-Selective Inhibition of Acyl Protein Thioesterases 1 and 2 (APT1 and APT2). ACS Chem Biol 11:3374-3382 (2016) [PubMed]  Article 
Target
Name:
Acyl-protein thioesterase 2 [M178L]
Synonyms:
LYPA2_HUMAN | LYPLA2 | APT2 | Acyl-protein thioesterase 2 (APT2 M178L)
Type:
Protein
Mol. Mass.:
24722.19
Organism:
Human
Description:
Human APT2 with M178L mutation
Residue:
231
Sequence:
MCGNTMSVPLLTDAATVSGAERETAAVIFLHGLGDTGHSWADALSTIRLPHVKYICPHAPRIPVTLNMKMVMPSWFDLMGLSPDAPEDEAGIKKAAENIKALIEHEMKNGIPANRIVLGGFSQGGALSLYTALTCPHPLAGIVALSCWLPLHRAFPQAANGSAKDLAILQCHGELDPLVPVRFGALTAEKLRSVVTPARVQFKTYPGVMHSSCPQEMAAVKEFLEKLLPPV
  
Inhibitor
Name:
BDBM207991
Synonyms:
ML348
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
c1cc(oc1)C(=O)N2CCN(CC2)CC(=O)Nc3cc(ccc3Cl)C(F)(F)F
Structure:
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