Reaction Details
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Acyl-protein thioesterase 1 [I75L,S82A,Q83P,R149H,A150R,S151A]
Ligand
BDBM207992
Substrate
n/a
Meas. Tech.
Steady-State Kinetic Assays
pH
6.5000±n/a
Ki
180±10 nM
Comments
extracted
Citation
Won, SJ; Davda, D; Labby, KJ; Hwang, SY; Pricer, R; Majmudar, JD; Armacost, KA; Rodriguez, LA; Rodriguez, CL; Chong, FS; Torossian, KA; Palakurthi, J; Hur, ES; Meagher, JL; Brooks, CL; Stuckey, JA; Martin, BR Molecular Mechanism for Isoform-Selective Inhibition of Acyl Protein Thioesterases 1 and 2 (APT1 and APT2). ACS Chem Biol 11:3374-3382 (2016) [PubMed] Article More Info.:
Target
Name:
Acyl-protein thioesterase 1 [I75L,S82A,Q83P,R149H,A150R,S151A]
Synonyms:
LYPA1_HUMAN | LYPLA1 | APT1 | LPL1 | Acyl-protein thioesterase 1 (APT1 I75L/S82A/Q83P/R149H/A150R/S151A)
Type:
Protein
Mol. Mass.:
24673.89
Organism:
Human
Description:
Human APT1 with I75L/S82A/Q83P/R149H/A150R/S151A mutations
Residue:
230
Sequence:
MCGNNMSTPLPAIVPAARKATAAVIFLHGLGDTGHGWAEAFAGIRSSHIKYICPHAPVRPVTLNMNVAMPSWFDLIGLSPDAPEDESGIKQAAENIKALIDQEVKNGIPSNRIILGGFSQGGALSLYTALTTQQKLAGVTALSCWLPLHRAFPQGPIGGANRDISILQCHGDCDPLVPLMFGSLTVEKLKTLVNPANVTFKTYEGMMHSSCQQEMMDVKQFIDKLLPPID
Inhibitor
Name:
BDBM207992
Synonyms:
ML349
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
COc1ccc(cc1)N1CCN(CC1)C(=O)c1cc2CS(=O)(=O)c3ccccc3-c2s1
Structure:
