Reaction Details
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Acyl-protein thioesterase 2 [S122A]
Ligand
BDBM207994
Substrate
n/a
Meas. Tech.
Fluorescence Binding Assays
Temperature
298.1500±n/a K
IC50
7.1e+3±n/a nM
Kd
2600±0.0 nM
Comments
extracted
Citation
Won, SJ; Davda, D; Labby, KJ; Hwang, SY; Pricer, R; Majmudar, JD; Armacost, KA; Rodriguez, LA; Rodriguez, CL; Chong, FS; Torossian, KA; Palakurthi, J; Hur, ES; Meagher, JL; Brooks, CL; Stuckey, JA; Martin, BR Molecular Mechanism for Isoform-Selective Inhibition of Acyl Protein Thioesterases 1 and 2 (APT1 and APT2). ACS Chem Biol 11:3374-3382 (2016) [PubMed] Article More Info.:
Target
Name:
Acyl-protein thioesterase 2 [S122A]
Synonyms:
LYPA2_HUMAN | LYPLA2 | APT2 | Acyl-protein thioesterase 2 (APT2 S122A)
Type:
Protein
Mol. Mass.:
24724.23
Organism:
Human
Description:
Human APT2 with S122A mutation
Residue:
231
Sequence:
MCGNTMSVPLLTDAATVSGAERETAAVIFLHGLGDTGHSWADALSTIRLPHVKYICPHAPRIPVTLNMKMVMPSWFDLMGLSPDAPEDEAGIKKAAENIKALIEHEMKNGIPANRIVLGGFAQGGALSLYTALTCPHPLAGIVALSCWLPLHRAFPQAANGSAKDLAILQCHGELDPMVPVRFGALTAEKLRSVVTPARVQFKTYPGVMHSSCPQEMAAVKEFLEKLLPPV
Inhibitor
Name:
BDBM207994
Synonyms:
ML349-sulfoxide
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
COc1ccc(cc1)N1CCN(CC1)C(=O)c1cc2CS(=O)c3ccccc3-c2s1
Structure:
