Target
Tyrosine-protein kinase JAK1 [852-1142]
Ligand
BDBM185700
Substrate
n/a
Meas. Tech.
JAK Enzymatic Assay
pH
7.4±n/a
IC50
9.53±n/a nM
Comments
extracted
Citation
 Mitton-Fry, MJBerlinski, PJBirchmeier, MJBowman, JWGonzales, AJKamerling, SGMann, DW Pyrrolo[2,3-D]pyrimidine compounds US Patent  US9271981 Publication Date 3/1/2016 
Target
Name:
Tyrosine-protein kinase JAK1 [852-1142]
Synonyms:
JAK1 | JAK1A | JAK1B | JAK1_HUMAN | Tyrosine-protein kinase JAK1
Type:
Protein
Mol. Mass.:
33337.85
Organism:
Homo sapiens (Human)
Description:
JAK1 truncation (852-1142 aa)
Residue:
291
Sequence:
NPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSF
  
Inhibitor
Name:
BDBM185700
Synonyms:
US10875847, Compound Oclacitinib | US9161939, 1a | US9271981, 1a
Type:
Small organic molecule
Emp. Form.:
C15H23N5O2S
Mol. Mass.:
337.44
SMILES:
CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnc2[nH]ccc12 |r,wU:9.12,wD:6.5,(5.44,3.81,;3.9,3.81,;2.56,3.04,;1.79,1.7,;3.33,1.7,;1.23,3.81,;-.1,3.04,;-1.44,3.81,;-2.77,3.04,;-2.77,1.5,;-1.44,.73,;-.1,1.5,;-4.1,.73,;-5.44,1.5,;-4.1,-.81,;-5.44,-1.58,;-5.44,-3.12,;-4.1,-3.89,;-2.77,-3.12,;-1.31,-3.6,;-.4,-2.35,;-1.31,-1.11,;-2.77,-1.58,)|
Structure:
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