Reaction Details
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Tyrosine-protein kinase JAK1 [852-1142]
Ligand
BDBM185701
Substrate
n/a
Meas. Tech.
JAK Enzymatic Assay
pH
7.4±n/a
IC50
45±n/a nM
Comments
extracted
Citation
Mitton-Fry, MJ; Berlinski, PJ; Birchmeier, MJ; Bowman, JW; Gonzales, AJ; Kamerling, SG; Mann, DW Pyrrolo[2,3-D]pyrimidine compounds US Patent US9271981 Publication Date 3/1/2016 More Info.:
Target
Name:
Tyrosine-protein kinase JAK1 [852-1142]
Synonyms:
JAK1 | JAK1A | JAK1B | JAK1_HUMAN | Tyrosine-protein kinase JAK1
Type:
Protein
Mol. Mass.:
33337.85
Organism:
Homo sapiens (Human)
Description:
JAK1 truncation (852-1142 aa)
Residue:
291
Sequence:
NPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSF
Inhibitor
Name:
BDBM185701
Synonyms:
US9161939, 2 | US9271981, 2
Type:
Small organic molecule
Emp. Form.:
C18H27N5O2S
Mol. Mass.:
377.504
SMILES:
CN([C@H]1CC[C@H](CS(=O)(=O)NC2CCC2)CC1)c1ncnc2[nH]ccc12 |r,wU:2.1,wD:5.5,(-6.28,1.54,;-4.94,.77,;-3.61,1.54,;-3.61,3.08,;-2.28,3.85,;-.94,3.08,;.39,3.85,;1.72,3.08,;.95,1.75,;2.49,1.75,;3.06,3.85,;4.39,3.08,;4.79,1.59,;6.28,1.99,;5.88,3.48,;-.94,1.54,;-2.28,.77,;-4.94,-.77,;-6.28,-1.54,;-6.28,-3.08,;-4.94,-3.85,;-3.61,-3.08,;-2.28,-3.85,;-.94,-3.08,;-.94,-1.54,;-3.61,-1.54,)|
Structure:
