Reaction Details Report a problem with these data
Target
Catenin beta-1 [138-686]/Transcription factor 4 [7-51]
Ligand
BDBM50094484
Substrate
n/a
Meas. Tech.
AlphaScreen Assay
pH
7.4000±n/a
Temperature
298.1500±n/a K
Ki
5870±960 nM
Comments
extracted
Citation
 Ji, H; Yu, B; Zhang, M; Guo, W Substituted 1H-indazol-1-ol analogs as inhibitors of beta catenin/Tcf protein-protein interactions US Patent  US9284299 Publication Date 3/15/2016 
Target
Name:
Catenin beta-1 [138-686]/Transcription factor 4 [7-51]
Synonyms:
Beta-catenin/Tcf4
Type:
Enzyme
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Catenin beta-1 [138-686]
Synonyms:
Beta-catenin | CTNB1_HUMAN | CTNNB1 | CTNNB
Type:
Protein
Mol. Mass.:
60127.24
Organism:
Human
Description:
aa 138-686
Residue:
549
Sequence:
NLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTE
  
Component 2
Name:
Transcription factor 4 [7-51]
Synonyms:
Transcription factor 4 (TCF4) | ITF2_HUMAN | TCF4 | BHLHB19 | ITF2 | SEF2
Type:
Enzyme
Mol. Mass.:
4569.48
Organism:
Human
Description:
Human Tcf4 truncation (7-51 aa)
Residue:
45
Sequence:
MAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVE
  
Inhibitor
Name:
BDBM50094484
Synonyms:
CHEMBL2323033 | CHEBI:3556 | US9284299, CGP049090 | US9738628, Compound CGP049090
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: