Reaction Details Report a problem with these data
Target
Cannabinoid receptor 1 [I218A]
Ligand
BDBM21278
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
pH
7.4000±n/a
Kd
2.5±0.6 nM
Comments
extracted
Citation
 Shim, JY; Ahn, KH; Kendall, DA Molecular basis of cannabinoid CB1 receptor coupling to the G protein heterotrimer Gaiß¿: identification of key CB1 contacts with the C-terminal helix a5 of Gai. J Biol Chem 288:32449-65 (2013) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 1 [I218A]
Synonyms:
CNR1_HUMAN | CNR1 | CNR | Cannabinoid receptor 1 (CB1 I218A)
Type:
Protein
Mol. Mass.:
52826.88
Organism:
Human
Description:
Human CB1 I218A mutant
Residue:
472
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISAHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
  
Inhibitor
Name:
BDBM21278
Synonyms:
SR141716 | 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide | CHEMBL111 | RIMONABANT HYDROCHLORIDE | [3H]Rimonabant | SR141716A | [3H]SR141716A | SR 141716A | CHEMBL558598 | Acomplia | Rimonabant
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: