Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase Chk1 [2-280]
Ligand
BDBM225341
Substrate
n/a
Meas. Tech.
33P-Radiometric_Method1
Ki
173±n/a nM
Citation
 D3R, DD Abbott CHK1 Kinase D3R 221:0 (2015) [PubMed] 
Target
Name:
Serine/threonine-protein kinase Chk1 [2-280]
Synonyms:
CHEK1 | CHK1 | CHK1_HUMAN | CHK1_Kinase
Type:
n/a
Mol. Mass.:
32109.16
Organism:
Homo sapiens (Human)
Description:
O14757[2-280]
Residue:
279
Sequence:
AVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTS
  
Inhibitor
Name:
BDBM225341
Synonyms:
Chk1_25
Type:
Small Organic Molecule
Emp. Form.:
C30H31N3O
Mol. Mass.:
449.5866
SMILES:
CC1CCC(CC1)NCc1ccc-2c(Cc3c-2n[nH]c3-c2ccc(cc2)-c2ccc(O)cc2)c1 |(-8.72,1.74,;-7.22,1.4,;-6.17,2.52,;-4.67,2.17,;-4.22,.7,;-5.27,-.43,;-6.77,-.08,;-2.72,.35,;-1.67,1.47,;-.17,1.12,;.28,-.35,;1.78,-.7,;2.83,.42,;2.39,1.89,;3.65,2.77,;4.88,1.84,;4.37,.39,;5.6,-.54,;6.86,.34,;6.42,1.81,;7.35,3.04,;6.75,4.46,;7.68,5.69,;9.21,5.5,;9.8,4.08,;8.88,2.85,;10.14,6.73,;9.54,8.14,;10.47,9.37,;12,9.18,;12.92,10.41,;12.59,7.76,;11.66,6.53,;.89,2.24,)|
Structure:
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