Target
GlcB
Ligand
BDBM50083940
Substrate
n/a
Meas. Tech.
DNTB-Coupled_Enzyme_Assay
IC50
170±n/a nM
Citation
 D3R, DD Sacchettini GlcB D3R 223:0 (2015) [PubMed]
Target
Name:
GlcB
Synonyms:
n/a
Type:
n/a
Mol. Mass.:
80350.85
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
741
Sequence:
MTDRVSVGNLRIARVLYDFVNNEALPGTDIDPDSFWAGVDKVVADLTPQNQALLNARDELQAQIDKWHRRRVIEPIDMDAYRQFLTEIGYLLPEPDDFTITTSGVDAEITTTAGPQLVVPVLNARFALNAANARWGSLYDALYGTDVIPETDGAEKGPTYNKVRGDKVIAYARKFLDDSVPLSSGSFGDATGFTVQDGQLVVALPDKSTGLANPGQFAGYTGAAESPTSVLLINHGLHIEILIDPESQVGTTDRAGVKDVILESAITTIMDFEDSVAAVDAADKVLGYRNWLGLNKGDLAAAVDKDGTAFLRVLNRDRNYTAPGGGQFTLPGRSLMFVRNVGHLMTNDAIVDTDGSEVFEGIMDALFTGLIAIHGLKASDVNGPLINSRTGSIYIVKPKMHGPAEVAFTCELFSRVEDVLGLPQNTMKIGIMDEERRTTVNLKACIKAAADRVVFINTGFLDRTGDEIHTSMEAGPMVRKGTMKSQPWILAYEDHNVDAGLAAGFSGRAQVGKGMWTMTELMADMVETKIAQPRAGASTAWVPSPTAATLHALHYHQVDVAAVQQGLAGKRRATIEQLLTIPLAKELAWAPDEIREEVDNNCQSILGYVVRWVDQGVGASKVPDIHDVALMEDRATLRISSQLLANWLRHGVITSADVRASLERMAPLVDRQNAGDVAYRPMAPNFDDSIAFLAAQELILSGAQQPNGYTEPILHRRRREFKARAAEKPAPSDRAGDDAAR
  
Inhibitor
Name:
BDBM50083940
Synonyms:
4-(3-Chloro-phenyl)-2-hydroxy-4-oxo-but-2-enoic acid (0.2H2O) | CHEMBL184215 | CHEMBL278763 | Sacchettini_6
Type:
Small organic molecule
Emp. Form.:
C10H7ClO4
Mol. Mass.:
226.613
SMILES:
OC(=O)C(=O)CC(=O)c1cccc(Cl)c1
Structure:
Search PDB for entries with ligand similarity: