Reaction Details Report a problem with these data
Target
Bromodomain-containing protein 4 [44-166,D144A]
Ligand
BDBM227644
Substrate
n/a
Meas. Tech.
TR-FRET Competition Assay
pH
7.5000±0.0000
Temperature
277.1500±0.0000 K
Kd
6.9e+3± 2.9e+3 nM
Citation
 Jung, M; Philpott, M; Müller, S; Schulze, J; Badock, V; Eberspächer, U; Moosmayer, D; Bader, B; Schmees, N; Fernández-Montalván, A; Haendler, B Affinity map of bromodomain protein 4 (BRD4) interactions with the histone H4 tail and the small molecule inhibitor JQ1. J Biol Chem 289:9304-19 (2014) [PubMed]  Article 
Target
Name:
Bromodomain-containing protein 4 [44-166,D144A]
Synonyms:
BRD4_HUMAN | BRD4 | HUNK1 | Bromodomain protein 4 bromodomain 1 (BRD4 BD1 D144A)
Type:
Protein
Mol. Mass.:
14567.28
Organism:
Human
Description:
Human BRD4 BD1 (44-166 aa) D144A mutant
Residue:
123
Sequence:
NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGADIVLMAEALEKLFLQKINELPT
  
Inhibitor
Name:
BDBM227644
Synonyms:
MSGRGKGGKGLGKGGAKRHRKVLRD | Histone H4 (1-25)
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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