Reaction Details Report a problem with these data
Target
Androgen receptor [646-919]
Ligand
BDBM227645
Substrate
n/a
Meas. Tech.
Mammalian Two-Hybrid Assay
IC50
4e+3±n/a nM
Citation
 Jehle, K; Cato, L; Neeb, A; Muhle-Goll, C; Jung, N; Smith, EW; Buzon, V; Carbó, LR; Estébanez-Perpiñá, E; Schmitz, K; Fruk, L; Luy, B; Chen, Y; Cox, MB; Bräse, S; Brown, M; Cato, AC Coregulator control of androgen receptor action by a novel nuclear receptor-binding motif. J Biol Chem 289:8839-51 (2014) [PubMed]  Article 
Target
Name:
Androgen receptor [646-919]
Synonyms:
ANDR_HUMAN | AR | DHTR | NR3C4 | Androgen receptor ligand-binding domain (AR-LBD)
Type:
Protein
Mol. Mass.:
31698.13
Organism:
Human
Description:
Human AR hinge-LBD (646-919 aa)
Residue:
274
Sequence:
ASSTTSPTEETTQKLTVSHIEGYECQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHT
  
Inhibitor
Name:
BDBM227645
Synonyms:
MAQRGGARRPRGDRERLGSR | Bag-1L (1-20)
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
CSCC[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O |r|
Structure:
Search PDB for entries with ligand similarity: