Reaction Details
Report a problem with these data
Report a problem with these dataTarget
Bone morphogenetic protein receptor type-1A
Ligand
BDBM148388
Substrate
n/a
Meas. Tech.
ALK1-6 enzymatic assays
pH
7.5000±n/a
IC50
225±n/a nM
Comments
extracted
Citation
Alimardanov, A; Cuny, GD; Grewal, GS; Lee, A; McKew, JC; Mohedas, AH; Shen, M; Xu, X; Yu, PB BMP inhibitors and methods of use thereof US Patent US9682983 Publication Date 6/20/2017 More Info.:
Target
Name:
Bone morphogenetic protein receptor type-1A
Synonyms:
BMR1A_HUMAN | BMPR1A | ACVRLK3 | ALK3 | Activin receptor-like kinase 3 (ALK-3)
Type:
Enzyme
Mol. Mass.:
60204.46
Organism:
Human
Description:
P36894
Residue:
532
Sequence:
MPQLYIYIRLLGAYLFIISRVQGQNLDSMLHGTGMKSDSDQKKSENGVTLAPEDTLPFLKCYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQCKDSPKAQLRRTIECCRTNLCNQYLQPTLPPVVIGPFFDGSIRWLVLLISMAVCIIAMIIFSSCFCYKHYCKSISSRRRYNRDLEQDEAFIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQGKPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPEVLDESLNKNHFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYEDMREVVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTLAKMVESQDVKI
Inhibitor
Name:
BDBM148388
Synonyms:
US9682983, 37 | US10017516, Compound 37
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
N#Cc1cc(ccc1N1CCNCC1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12
Structure:
