Reaction Details
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Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
Ligand
BDBM228808
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Assay
pH
8.0000±n/a
Kd
3.2e+4± 1.1e+3 nM
Comments
extracted
Citation
Jenkins, RJ; Heslip, KA; Meagher, JL; Stuckey, JA; Dotson, GD Structural basis for the recognition of peptide RJPXD33 by acyltransferases in lipid A biosynthesis. J Biol Chem 289:15527-35 (2014) [PubMed] Article More Info.:
Target
Name:
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
Synonyms:
LPXA_ECOLI | lpxA | UDP-N-acetylglucosamine acryltransferase (LpxA)
Type:
Enzyme
Mol. Mass.:
28083.70
Organism:
Escherichia coli (strain K12)
Description:
P0A722
Residue:
262
Sequence:
MIDKSAFVHPTAIVEEGASIGANAHIGPFCIVGPHVEIGEGTVLKSHVVVNGHTKIGRDNEIYQFASIGEVNQDLKYAGEPTRVEIGDRNRIRESVTIHRGTVQGGGLTKVGSDNLLMINAHIAHDCTVGNRCILANNATLAGHVSVDDFAIIGGMTAVHQFCIIGAHVMVGGCSGVAQDVPPYVIAQGNHATPFGVNIEGLKRRGFSREAITAIRNAYKLIYRSGKTLDEVKPEIAELAETYPEVKAFTDFFARSTRGLIR
Inhibitor
Name:
BDBM228808
Synonyms:
FITC-(βa)TNLYM(L-photoleucine)PKWDIP-CONH2 | FITC-Photo 3
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
CC[C@H](C)[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC1(C)N=N1)NC(=O)[C@H](CCSC)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)CCNC(=S)Nc1ccc(c(c1)C(O)=O)-c1c2ccc(O)cc2oc2cc(=O)ccc12)[C@@H](C)O)C(=O)N1CCC[C@H]1C(O)=O |r,wU:126.136,75.84,55.63,91.96,39.40,16.28,4.4,wD:83.92,63.76,46.55,30.37,8.12,2.2,135.145,c:53,(58.94,-19.08,;58.41,-20.52,;59.4,-21.7,;60.92,-21.43,;58.87,-23.15,;
Structure:
