Reaction Details
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Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
Ligand
BDBM228812
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Assay
pH
8.0000±n/a
Kd
2.3e+4± 2.0e+3 nM
Comments
extracted
Citation
Jenkins, RJ; Heslip, KA; Meagher, JL; Stuckey, JA; Dotson, GD Structural basis for the recognition of peptide RJPXD33 by acyltransferases in lipid A biosynthesis. J Biol Chem 289:15527-35 (2014) [PubMed] Article More Info.:
Target
Name:
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
Synonyms:
LPXA_ECOLI | lpxA | UDP-N-acetylglucosamine acryltransferase (LpxA)
Type:
Enzyme
Mol. Mass.:
28083.70
Organism:
Escherichia coli (strain K12)
Description:
P0A722
Residue:
262
Sequence:
MIDKSAFVHPTAIVEEGASIGANAHIGPFCIVGPHVEIGEGTVLKSHVVVNGHTKIGRDNEIYQFASIGEVNQDLKYAGEPTRVEIGDRNRIRESVTIHRGTVQGGGLTKVGSDNLLMINAHIAHDCTVGNRCILANNATLAGHVSVDDFAIIGGMTAVHQFCIIGAHVMVGGCSGVAQDVPPYVIAQGNHATPFGVNIEGLKRRGFSREAITAIRNAYKLIYRSGKTLDEVKPEIAELAETYPEVKAFTDFFARSTRGLIR
Inhibitor
Name:
BDBM228812
Synonyms:
TNLYML-CONH2 | RJPXD33Δ6
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
CSCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)[C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(N)=O |r|
Structure:
