Reaction Details
Report a problem with these data
Report a problem with these dataTarget
cDNA, FLJ78895, highly similar to 3-oxo-5-alpha-steroid 4-dehydrogenase 1
Ligand
BDBM50025356
Substrate
n/a
Meas. Tech.
5α-Reductase Activity Assay
pH
6.5000±0.0000
Temperature
310.1500±0.0000 K
IC50
1.3±0.4 nM
Citation
Cabeza, M; Trejo, KV; González, C; García, P; Soriano, J; Heuze, Y; Bratoeff, E Steroidal 5a-reductase inhibitors using 4-androstenedione as substrate. J Enzyme Inhib Med Chem 26:712-9 (2011) [PubMed] Article More Info.:
Target
Name:
cDNA, FLJ78895, highly similar to 3-oxo-5-alpha-steroid 4-dehydrogenase 1
Synonyms:
5-alpha-Reductase (5α-Reductase)
Type:
Enzyme
Mol. Mass.:
24182.16
Organism:
Human
Description:
EC 1.3.99.5; B7Z4L2
Residue:
212
Sequence:
MEHAAQPWRWQRRRGWRRSACWPRSPTCSAPWAARSSRGIVRRTQCTAATRCPATGSECRRGPPGWCRSCPRWPCRSTSTPASPPRVSAARPTASSWPCSSSTTGIGFGLWLTGMLINIHSDHILRNLRKPGDTGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEWYLRKFEEYPKFRKIIIPFLF
Inhibitor
Name:
BDBM50025356
Synonyms:
4a,6a-Dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid tert-butylamide | N-tert-butyl-2,15-dimethyl-5-oxo-6-azatetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-3-ene-14-carboxamide | CHEMBL710 | Finasteride
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2C(=O)NC(C)(C)C)CC[C@@H]4[C@@]3(C=CC(=O)N4)C
Structure:
