Reaction Details Report a problem with these data
Target
Carbonic anhydrase 13 + BH
Ligand
BDBM10880
Substrate
n/a
Meas. Tech.
CA Activity Assay
pH
7.5000±n/a
Ki
179±0.0 nM
Comments
50 mM acetaldehyde extracted
Citation
 Bootorabi, F; Jänis, J; Hytönen, VP; Valjakka, J; Kuuslahti, M; Vullo, D; Niemelä, O; Supuran, CT; Parkkila, S Acetaldehyde-derived modifications on cytosolic human carbonic anhydrases. J Enzyme Inhib Med Chem 26:862-70 (2011) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 13 + BH
Synonyms:
CA XIII + BH
Type:
Protein
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Carbonic anhydrase 13
Synonyms:
Carbonic anhydrase XIII (CA XIII) | CAH13_HUMAN | CA13 | Carbonic anhydrase | Carbonic anhydrase 13 (CA XIII)
Type:
Enzyme
Mol. Mass.:
29445.78
Organism:
Human
Description:
Q8N1Q1
Residue:
262
Sequence:
MSRLSWGYREHNGPIHWKEFFPIADGDQQSPIEIKTKEVKYDSSLRPLSIKYDPSSAKIISNSGHSFNVDFDDTENKSVLRGGPLTGSYRLRQVHLHWGSADDHGSEHIVDGVSYAAELHVVHWNSDKYPSFVEAAHEPDGLAVLGVFLQIGEPNSQLQKITDTLDSIKEKGKQTRFTNFDLLSLLPPSWDYWTYPGSLTVPPLLESVTWIVLKQPINISSQQLAKFRSLLCTAEGEAAAFLVSNHRPPQPLKGRKVRASFH
  
Component 2
Name:
BDBM235669
Synonyms:
Sodium cyanoborohydride
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
[BH3-]C#N
Structure:
Search PDB for entries with ligand similarity:
Inhibitor
Name:
BDBM10880
Synonyms:
Acetazolamide, AAZ | AZA2 | CHEMBL20 | Acetazolamide | N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide | Acetazolamide, AZA | AZA | Acetazolamide, 5 | Sulfonamide, 1 | Acerazolamide, AAZ | Acetazolamide, AZM | sulfonamide 1 | Acetazolamide (AAZ) | Acetazolamide (AZM) | AZM acetazolamide | Acetazolamide (AZA) | US10172837, Acetazolamide | US11278534, Example acetazolamide | US11535599, Example acetazolamide
Type:
Small organic molecule
Emp. Form.:
C4H6N4O3S2
Mol. Mass.:
221.99
SMILES:
CC(=O)Nc1nnc(s1)S(=O)(=O)N
Structure:
Search PDB for entries with ligand similarity: