Reaction Details Report a problem with these data
Target
Carbonic anhydrase 4
Ligand
BDBM10882
Substrate
n/a
Meas. Tech.
Esterase Activity Assay
pH
7.4000±n/a
Ki
840±n/a nM
Comments
extracted
Citation
 Ekinci, D; Karagoz, L; Ekinci, D; Senturk, M; Supuran, CT Carbonic anhydrase inhibitors: in vitro inhibition of a isoforms (hCA I, hCA II, bCA III, hCA IV) by flavonoids. J Enzyme Inhib Med Chem 28:283-8 (2013) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 4
Synonyms:
Carbonic anhydrase 4 (CA IV) | Carbonic anhydrase IV (CA IV) | CA-IV | Carbonate dehydratase IV | CAH4_HUMAN | CA4 | Carbonic anhydrase
Type:
Enzyme
Mol. Mass.:
35037.98
Organism:
Human
Description:
P22748
Residue:
312
Sequence:
MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR
  
Inhibitor
Name:
BDBM10882
Synonyms:
6-ethoxy-1,3-benzothiazole-2-sulfonamide | Ethoxzolamide, EZM | Sulfonamide, 3 | CHEMBL18 | sulfonamide 3 | Ethoxzolamide (EZA) | Ethamide | Ethoxazolamide | Ethoxzolamide | US10172837, Ethoxyzolamide
Type:
Small organic molecule
Emp. Form.:
C9H10N2O3S2
Mol. Mass.:
258.01
SMILES:
CCOc1ccc2c(c1)sc(n2)S(=O)(=O)N
Structure:
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