Reaction Details Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM237338
Substrate
n/a
Meas. Tech.
Carbonic Anhydrase I, II, IV and XII Assay
pH
7.5000±n/a
Temperature
298.1500±n/a K
IC50
81.1±0.0 nM
Comments
extracted
Citation
 Supuran, CT; Maresca, A; Gregán, F; Remko, M Three new aromatic sulfonamide inhibitors of carbonic anhydrases I, II, IV and XII. J Enzyme Inhib Med Chem 28:289-93 (2013) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CAH2_HUMAN | CA2 | CA-II | CAC | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Human
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM237338
Synonyms:
N-(4-diethylaminoethoxybenzyl)benzene-1,4-bis-sulfonamide (I-3)
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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