Reaction Details Report a problem with these data
Target
Epidermal growth factor receptor [668-1210]
Ligand
BDBM238272
Substrate
n/a
Meas. Tech.
Omnia Assay
pH
7.5000±n/a
IC50
200±n/a nM
Comments
extracted
Citation
 Lee, K; Niu, D; Baevsky, MF Mutant-selective EGFR inhibitors and uses thereof US Patent  US9409887 Publication Date 8/9/2016 
Target
Name:
Epidermal growth factor receptor [668-1210]
Synonyms:
EGFR_HUMAN | EGFR | ERBB | ERBB1 | HER1 | Epidermal growth factor receptor (EGFR) | Receptor tyrosine-protein kinase ErbB-1 | EGF-R Tyrosine Kinase
Type:
Cytoplasmic region
Mol. Mass.:
61304.06
Organism:
Human
Description:
Wildtype EGFR was purchased from Invitrogen.
Residue:
543
Sequence:
MRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA
  
Inhibitor
Name:
BDBM238272
Synonyms:
US9409887, I-3
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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